Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Synthetic Route of 1603-41-4.
Uysal, Sirin;Soyer, Zeynep;Saylam, Merve;Tarikogullari, Ayse H.;Yilmaz, Sinem;Kirmizibayrak, Petek Ballar research published 《 Design, synthesis and biological evaluation of novel naphthoquinone-4-aminobenzensulfonamide/carboxamide derivatives as proteasome inhibitors》, the research content is summarized as follows. A series of novel 4-aminobenzensulfonamide/carboxamide derivatives I [R = 2-ethylanilino, (2-chloro-3-pyridyl)amino, 1-naphthylamino, etc.] and II [R1 = anilino, 2-thiazolylamino, 4-nitroanilino, etc.] were designed, sythesized and evaluated for their proteasome inhibitory and antiproliferative activities against human breast cancer cell line (MCF-7). The structures of the synthesized compounds I and II were confirmed by spectral and elemental analyses. The proteasome inhibitory activity studies were carried out using cell-based assay. The antiproteasomal activity results revealed that most of the compounds exhibited inhibitory activity with different percentages against the caspase-like (C-L, β1 subunit), trypsin-like (T-L, β2 subunit) and chymotrypsin-like (ChT-L, β5 subunit) activities of proteasome. Among the tested compounds, compound I [R = (5-chloro-2-pyridyl)amino] was the most active compound in the series and displayed higher inhibition with IC50 values of 9.90 ± 0.61, 44.83 ± 4.23 and 22.27 ± 0.15μM against ChT-L, C-L and T-L activities of proteasome compared to the lead compound PI-083 (IC50 = 12.47 ± 0.21, 53.12 ± 2.56 and 26.37 ± 0.5μM), resp. The antiproliferative activity were also determined by MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay in-vitro. According to the antiproliferative activity results, all of the compounds I and II exhibited cell growth inhibitory activity in a range of IC50 = 1.72 ± 0.14-20.8 ± 0.5μM and compounds I [R = (5-methyl-2-pyridyl)amino] and II [R1 = (4-methyl-2-pyridyl)amino] were found to be the most active compounds with IC50 values of 1.79 ± 0.21 and 1.72 ± 0.14μM, resp. Furthermore, mol. modeling studies were carried out for the compounds I [R = (5-methyl-2-pyridyl)amino, (5-chloro-2-pyridyl)amino] and II [R1 = (4-methyl-2-pyridyl)amino] to investigate the ligand-enzyme binding interactions.
Synthetic Route of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.