van Winden, Tms published the artcileEffects of tocolysis with nifedipine or atosiban on child outcome: follow-up of the APOSTEL III trial, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is nifedipine atosiban preterm birth; Atosiban; behaviour; child; development; executive function; follow-up; health; infant; neurodevelopment; nifedipine; preterm birth; preterm labour; tocolysis.
Objective : To compare the long-term effects of tocolysis with nifedipine or atosiban on child outcome at age 2.5-5.5 years. Design : The APOSTEL III trial was a multicentre randomised controlled trial that compared tocolysis with nifedipine or atosiban in 503 women with threatened preterm birth. Methods : Parents were asked to complete four questionnaires regarding neurodevelopment, executive function, behavior problems and general health. Main outcome measures : The main long-term outcome measure was a composite of abnormal development at the age of 2.5-5.5 years. Results : Of the 426 women eligible for follow-up, 196 parents returned the questionnaires for 115 children in the nifedipine group and 110 children in the atosiban group. Abnormal development occurred in 32 children in the nifedipine group and in 38 children in the atosiban group (OR 0.74, 95% CI 0.41-1.34). Sensitivity anal. for all children of the APOSTEL III trial, including a comparison of deceased children, resulted in a higher rate of healthy survival in the nifedipine group (64 vs. 54%), but there was no significant difference in the overall mortality rate (5.4 vs. 2.7%). Conclusion : Outcomes on broad child neurodevelopment, executive function, behavior and general health were comparable in both groups. Tweetable abstract : Nifedipine- and atosiban-exposed children had comparable long-term outcomes, including neurodevelopment, executive function and behavior.
BJOG published new progress about Behavior. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.