Nitrogen bridgehead compounds. Part 5. Cyclization of 2-(2-pyridylaminomethylene)-succinates and -glutarates was written by Vasvari-Debreczy, Lelle;Hermecz, Istvan;Meszaros, Zoltan;Horvath, Agnes;Simon-Parkanyi, Piroska. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1978.Category: pyridine-derivatives This article mentions the following:
Cyclization of succinates I (n = 1, R = H, alkyl, OH, Cl, NO2, NHCOMe, CONH2) gave 40-92% pyrido[1,2-a]pyrimidines and pyridylpyrrolinones. The latter may form pyridylpyrroles by reaction with POCl3. The ratio of pyridopyrimidines to pyridylpyrroles was dependent upon the nature and position of the pyridine ring substituent. Substituents at position 6 hindered pyridopyrimidine formation whereas those at position 3 inhibited the formation of pyridylpyrrolinones. Only pyrido[1,2-a]pyrimidines were formed from the cyclization of the homologous glutarates I (n = 2). In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Category: pyridine-derivatives).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives