Venkateshwarlu, Rapolu published the artcileUltrasound assisted one-pot synthesis of 1,2-diaryl azaindoles via Pd/C-Cu catalysis: Identification of potential cytotoxic agents, Application of 2-Bromopyridin-3-amine, the publication is Tetrahedron Letters (2019), 60(52), 151326, database is CAplus.
Ultrasound assisted one-pot and direct access to 1,2-diaryl substituted azaindole derivatives I [W = CH, N; X = CH, N; Y = CH, N; Z = CH, N; Ar1 = Ph, 4-ClC6H4, 4-MeC6H4; Ar2 = 4-CNC6H4, 4-MeOC6H4, 4-Me(SO2)C6H4, etc.] was achieved via the sequential N-arylation followed by coupling-cyclization under Pd/C-Cu catalysis. The methodol. involved initial C-N bond forming reaction (step 1) between an appropriate o-bromo substituted amino pyridine and iodoarene followed by C-C and C-N bond formation (step 2) between the resulting N-aryl substituted intermediate and a terminal alkyne in the same pot. A variety of azaindoles were prepared by using this method. These compounds were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g. MDA-MB-231 and MCF-7. Compounds I [W = Y = Z = CH, X = N, Ar1 = 4-MeC6H4, Ar2 = 4-MeOC6H4], I [W = Y = Z = CH, X = N, Ar1 = Ph, Ar2 = 4-MeOC6H4] and I [W = Y = Z = CH, X = N, Ar1 = 4-ClC6H4, Ar2 = 3,5-di-MeOC6H3] showed promising growth inhibition of these cell lines and SIRT1 inhibition in vitro.
Tetrahedron Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C15H24O2, Application of 2-Bromopyridin-3-amine.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem