C-H bond cyanation of arenes using N,N-dimethylformamide and NH4HCO3 as a CN source over a hydroxyapatite supported copper catalyst was written by Venu, Boosa;Vishali, Bilakanti;Naresh, Gutta;Kumar, Velisoju Vijay;Sudhakar, Medak;Kishore, Ramineni;Beltramini, Jorge;Konarova, Muxina;Venugopal, Akula. And the article was included in Catalysis Science & Technology in 2016.HPLC of Formula: 4373-61-9 This article mentions the following:
A hydroxyapatite supported Cu catalyst [HAP:Ca5(PO4)3(OH)] has been found to be an efficient and reusable heterogeneous catalyst for safe cyanation of C-H bonds of heteroaryl compounds The combination of NH4HCO3 and DMF is identified as a CN source under mild reaction conditions. 10 wt% Cu/HAP offered good to excellent yields compared to Ru/HAP and Pd/HAP catalysts. The surface basicity and Cu metal surface area of the catalysts played a significant role in the cyanation reaction through C-H bond activation. The catalyst was recovered and reused for five cycles showing consistent activity and selectivity. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 4373-61-9