The author of 《Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase》 were Vishwanath, Divakar; Girimanchanaika, Swamy S.; Dukanya, Dukanya; Rangappa, Shobith; Yang, Ji-Rui; Pandey, Vijay; Lobie, Peter E.; Basappa, Basappa. And the article was published in Molecules in 2022. Name: (6-Chloro-5-methylpyridin-3-yl)boronic acid The author mentioned the following in the article:
Novel PARP inhibitors with selective mode-of-action have been approved for clin. use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells, wherein seven compounds were observed to possess significant IC50 values in the range of 1.4 to 25 μM. Furthermore, compound 5u, inhibited the viability of MCF-7 cells with an IC50 value of 1.4μM, when compared to Olaparib (IC50 = 3.2 μM). Compound 5s also decreased cell viability in MCF-7 and MDA-MB-231 cells with IC50 values of 15.3 and 19.2 μM, resp. Treatment of MCF-7 cells with compounds 5u and 5s produced PARP cleavage, H2AX phosphorylation and CASPASE-3 activation comparable to that observed with Olaparib. Compounds 5u and 5s also decreased foci-formation and 3D Matrigel growth of MCF-7 cells equivalent to or greater than that observed with Olaparib. Finally, in silico anal. demonstrated binding of compound 5s towardsthe catalytic site of PARP-1, indicating that these novel oxadiazoles synthesized herein may serve as exemplars for the development of new therapeutics in cancer. In the part of experimental materials, we found many familiar compounds, such as (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Name: (6-Chloro-5-methylpyridin-3-yl)boronic acid)
(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Name: (6-Chloro-5-methylpyridin-3-yl)boronic acid