In 2022,Voelkel, Martin H. H.; Engelage, Elric; Kondratiuk, Mykhailo; Huber, Stefan M. published an article in European Journal of Organic Chemistry. The title of the article was 《Evaluation of 6-Halogenated 2-Pyridone Moieties as Halogen Bond Donors》.Safety of 2,6-Dibromopyridine The author mentioned the following in the article:
6-Halo-2-pyridones and their pyridol tautomers show different grades of polarization on their halogen substituents in DFT calculations This and the fact that the tautomeric equilibrium was affected by the surrounding medium make them interesting candidates for a new platform of halogen bond donors. Therefore four simple halopyridones was probed for their halogen bonding properties both in the solid state and in solution Concurring with hydrogen bonding, halogen bonding indeed was found to be an interaction governing the packing motif in pyridone crystals, which was more pronounced in N-methylated congeners. Solution studies using a halide abstraction reaction and NMR titrations against bromide salts, however, showed no clear evidence for halogen bonding in solution After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Safety of 2,6-Dibromopyridine)
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of 2,6-Dibromopyridine