On December 31, 2018, Wang, Bingbing; Parobchak, Nataliya; Martin, Adriana; Rosen, Max; Yu, Lumeng Jenny; Nguyen, Mary; Gololobova, Kseniya; Rosen, Todd published an article.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Screening a small molecule library to identify inhibitors of NF-kappaB inducing kinase and pro-labor genes in human placenta. And the article contained the following:
The non-canonical NF-kappaB signaling (RelB/p52) pathway drives pro-labor genes in the human placenta, including corticotropin-releasing hormone (CRH) and cyclooxygenase-2 (COX-2), making this a potential therapeutic target to delay onset of labor. Here we sought to identify small mol. compounds from a pre-existing chem. library of orally active drugs that can inhibit this NF-kappaB signaling, and in turn, human placental CRH and COX-2 production We used a cell-based assay coupled with a dual-luciferase reporter system to perform an in vitro screening of a small mol. library of 1,120 compounds for inhibition of the non-canonical NF-kappaB pathway. Cell toxicity studies and drug efflux transport MRP1 assays were used to further characterize the lead compounds We have found that 14 drugs have selective inhibitory activity against lymphotoxin beta complex-induced activation of RelB/p52 in HEK293T cells, several of which also inhibited expression of CRH and COX-2 in human term trophoblast. We identified sulfapyridine and propranolol with activity against CRH and COX-2 that deserve further study. These drugs could serve as the basis for development of orally active drugs to affect length of gestation, first in an animal model, and then in clin. trials to prevent preterm birth during human pregnancy. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate
The Article related to placenta nf kappa b small mol, Pharmacology: Methods and other aspects.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate