In 2018,Wang, Dong; Shen, Meng; Wang, Yuxi; Hu, Jianyong; Zhao, Junjie; Yu, Peng published 《Access to Furo[2,3-b]pyridines by Transition-Metal-Free Intramolecular Cyclization of C3-substituted Pyridine N-oxides》.Asian Journal of Organic Chemistry published the findings.HPLC of Formula: 53939-30-3 The information in the text is summarized as follows:
Two transition-metal-free synthetic methods for the construction of furo[2,3-b]pyridines such as I [R = H, 5-F, 5-Me, etc.; R1 = Me, Et, Ph, etc.; R2 = Me, Et, Ph, etc.] from corresponding C3-substituted-pyridine-N-oxides were developed by regioselective intramol. nucleophilic addition/rearomatization strategy. Remarkable features of these methods include simple operation, wide substrate scope and easily accessible starting materials. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3HPLC of Formula: 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 53939-30-3