Wang, Haixia; Robl, Jeffrey A.; Hamann, Lawrence G.; Simpkins, Ligaya; Golla, Rajasree; Li, Yi-Xin; Seethala, Ramakrishna; Zvyaga, Tatyana; Gordon, David A.; Li, James J. published the artcile< Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)>, Category: pyridine-derivatives, the main research area is triazolopyridine derivative inhibitor human hydroxysteroid dehydrogenase.
A series of pyridyl amide/sulfonamide inhibitors of 11β-HSD-1 were modified to incorporate a novel 1,2,4-triazolopyridine scaffold. Optimization of substituents at the 3 and 8 position of the TZP core, with a special focus on enhancing metabolic stability, resulted in the identification of compound 38 as a potent and metabolically stable inhibitor of the enzyme.
Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Category: pyridine-derivatives.