Wang, Jun; Xu, Guan-Cheng; Zhang, Yan-Ping; Luo, Hua-Ying; Li, Jin-Yao; Zhang, Li; Jia, Dian-Zeng published the artcile< Copper(II) complexes with 4-acyl pyrazolone derivatives and diimine coligands: synthesis, structural characterization, DNA binding and antitumor activity>, Product Details of C10H8N2, the main research area is antitumor agent copper dipyridyl pyrazolone salicylidene derived complex; crystal structure copper dipyridyl pyrazolone salicylidene derived complex preparation; electrochem redox potential copper dipyridyl pyrazolone salicylidene derived complex.
Three mixed-ligand Cu(II) complexes [Cu(L)(bpy)] (1), [Cu(L)(phen)] (2) and [Cu(L)(dpq)]·CHCl3 (3) have been synthesized and fully characterized, where H2L = N-(1-phenyl-3-methyl-4-(4-fluorobenzoyl)-5-pyrazolone)-2-salicylidene hydrazide, bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline and dpq = dipyrido[3,2-d:2′,3′-f]quinoxaline. Single crystal x-ray diffraction anal. revealed that complexes 1-3 have mononuclear structure and the Cu(II) ions are located in a five-coordinated distorted square pyramidal geometry. The interaction of the compounds with herring sperm DNA has been studied by absorption titration, ethidium bromide displacement experiments and electrochem. studies. All the compounds could interact intercalatively with DNA, and complex 3 shows the highest DNA binding ability, followed by 2, 1 and H2L. Complexes 1-3 exhibit excellent cytotoxicity against cervical cancer HeLa cells and human esophageal cancer Eca-109 cells. Complex 3 displays the best activity for both cancer cell lines, and the IC50 values are 4.37 ± 0.08 μM and 3.68 ± 0.14 μM for HeLa and Eca-109 cells, resp., which are ∼13 times lower than that of the com. antitumor drug cisplatin. Moreover, complex 3 dose-dependently induces Eca-109 cell apoptosis characterized by nuclear morphol. changes and increased Annexin V+ cells, suggesting that complex 3 inhibited the proliferation of Eca-109 cells by induction of apoptosis. In conclusion, the mixed-ligand complex 3 might be a potential antitumor drug.
New Journal of Chemistry published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.