Wang, Qing-Dong; Zhang, Si-Xuan; Zhang, Zhuo-Wen; Wang, Ying; Ma, Mengtao; Chu, Xue-Qiang; Shen, Zhi-Liang published the artcile< Palladium-Catalyzed Sonogashira Coupling of a Heterocyclic Phosphonium Salt with a Terminal Alkyne>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is palladium copper catalyst Sonogashira coupling heterocyclic phosphonium terminal alkyne; pyridine quinoline pyrazine quinoxaline alkynyl preparation functionalized.
An efficient Sonogashira coupling of a heterocyclic phosphonium salt with a terminal alkyne via C-P bond cleavage was developed. The reactions proceeded smoothly in the presence of palladium catalyst, copper(I) iodide, and N,N-diisopropylethylamine (DIPEA) in N-methyl-2-pyrrolidone (NMP) at 100°C for 12 h, producing the corresponding alkynyl-substituted pyridine, quinoline, pyrazine, and quinoxaline in moderate to good yields with wide substrate scope and broad functional group tolerance. In addition, gram-scale synthesis could also be achieved, and the reaction could be applied to the functionalization of alkyne-containing complex mols. derived from sugars and pharmaceutical and naturally occurring products (e.g., estrone, D-galactopyranose, menthol, and ibuprofen).
Organic Letters published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.