On September 11, 2014, Wang, Shaomeng; Ran, Xu; Zhao, Yujun; Yang, Chao-Yie; Liu, Liu; Bai, Longchuan; McEachern, Donna; Stuckey, Jeanne; Meagher, Jennifer Lynn; Sun, Duxin; Li, Xiaoqin; Zhou, Bing; Karatas, Hacer; Luo, Ruijuan; Chinnaiyan, Arul; Asangani, Irfan A. published a patent.Quality Control of 4-Bromo-2-isopropylpyridine The title of the patent was Preparation of pyridoindole, pyridazinoindole and pyrimidinoindole compounds as BET bromodomain inhibitors. And the patent contained the following:
The title compounds I [X = NRa, O or S; Y1, Y3 = CH or N; Y2 = CH, CRa (wherein Ra = H, alkyl, benzyl), or absent; Z = H, II (wherein B = (un)substituted aryl, heteroaryl, heterocycloalkyl, etc.; Rb = alkyl, halo, aryl, etc.; n = 0-3), G(L)C(Rc)3 (G = N, O, or S; L = absent, H, C(Rd)3; Rc, Rd = H, alkyl, (un)substituted aryl, etc.), halo, OH, or absent; A = (un)substituted 5-membered heterocyclyl; R1 = H, halo, OH, etc.] that are inhibitors of BET bromodomains useful in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, were prepared E.g., a multi-step synthesis of III, starting from 4-hydroxypyridin-2(1H)-one, was described. The ability of exemplified compounds I to bind to BET bromodomain proteins was evaluated (data given for representative compounds I). Pharmaceutical compositions comprising compound I, alone or in combination with second therapeutic agent, surgery and radiation, were disclosed. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Quality Control of 4-Bromo-2-isopropylpyridine
The Article related to pyridoindole pyridazinoindole pyrimidinoindole preparation bet bromodomain inhibitor antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 4-Bromo-2-isopropylpyridine