Rapid determination of chemical composition in the particulate matter of cigarette mainstream smoke was written by Wang, Xinxin;Jiang, Qing;Li, Hongli;Chen, David D. Y.. And the article was included in Talanta in 2020.Quality Control of Pyridin-4-ol This article mentions the following:
Particulate matter from mainstream smoke (MSS) is significantly hazardous when inhaled into the human body. An ambient ionization mass spectrometric method, direct anal. in real time mass spectrometry (DART-MS), was applied to rapidly and simultaneously measure multiple particulate components in MSS. A variety of compounds were obtained in seconds, where different types of cigarettes and different solvent extracts generated distinct chem. constituents as validated by principle component anal. Chem. formula assignment and compound identification were based on accurate m/z values with mass errors <10 ppm. Quantitation of nicotine was achieved using an isotope internal standard with DART-MS. Method validation with chromatog.-MS anal. further proved the advantages of DART-MS with respect to anal. speed and operational simplicity for the direct evaluation of complex samples. DART-MS is feasible for the rapid acquisition of cigarette fingerprints for quality control as well as for quant. assessment of carcinogens for harm reduction In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of Pyridin-4-ol