Electrochemically enabled rhodium-catalyzed [4+2] annulations of arenes with alkynes was written by Wang, Zi-Chen;Li, Rui-Tao;Ma, Qiang;Chen, Jia-Yi;Ni, Shao-Fei;Li, Ming;Wen, Li-Rong;Zhang, Lin-Bao. And the article was included in Green Chemistry in 2021.COA of Formula: C12H11N This article mentions the following:
Electrochem. driven, Rh(III)-catalyzed regioselective annulations of arenes with alkynes was established. The strategy, combining the use of a rhodium catalyst with electricity, not only avoided the need for using a stoichiometric amount of external oxidant, but also ensured that the transformations proceeded under mild and green conditions, which enabled broad functional group compatibility with a variety of substrates, including drugs and pharmaceutical motifs. Moreover, the electrolysis reaction was made operationally simple by employing an undivided cell and proceeded efficiently in aqueous solution in air. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9COA of Formula: C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.COA of Formula: C12H11N