In 2017,Wappes, Ethan A.; Nakafuku, Kohki M.; Nagib, David A. published 《Directed β C-H Amination of Alcohols via Radical Relay Chaperones》.Journal of the American Chemical Society published the findings.Recommanded Product: 103-74-2 The information in the text is summarized as follows:
A radical-mediated strategy for β C-H amination of alcs. has been developed. This approach employs a radical relay chaperone, which serves as a traceless director that facilitates selective C-H functionalization via 1,5-hydrogen atom transfer (HAT) and enables net incorporation of ammonia at the β carbon of alcs. The chaperones presented herein enable direct access to imidate radicals, allowing their first use for H atom abstraction. A streamlined protocol enables rapid conversion of alcs. to their β-amino analogs (via in situ conversion of alcs. to imidates, directed C-H amination, and hydrolysis to NH2). Mechanistic experiments indicate HAT is rate-limiting, whereas intramol. amination is product- and stereo-determining In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 103-74-2) was used in this study.
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 103-74-2