Weber, Stefan; Bruenig, Julian; Veiros, Luis F.; Kirchner, Karl published their research in Organometallics in 2021. The article was titled ãManganese-Catalyzed Hydrogenation of Ketones under Mild and Base-free Conditionsã?Category: pyridine-derivatives The article contains the following contents:
In this paper, several Mn(I) complexes were applied as catalysts for the homogeneous hydrogenation of ketones. The most active precatalyst is the bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dippe)(CO)3(CH2CH2CH3)]. The reaction proceeds at room temperature under base-free conditions with a catalyst loading of 3 mol % and a hydrogen pressure of 10 bar. A temperature-dependent selectivity for the reduction of α,β-unsaturated carbonyls was observed At room temperature, the carbonyl group was selectively hydrogenated, while the C:C bond stayed intact. At 60°, fully saturated systems were obtained. A plausible mechanism based on DFT calculations which involves an inner-sphere hydride transfer is proposed. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives