In an article, author is Sampani, Stavroula I., once mentioned the application of 220000-87-3, SDS of cas: 220000-87-3, Name is 4-Chloro-N-methylpicolinamide, molecular formula is C7H7ClN2O, molecular weight is 170.6, MDL number is MFCD02185921, category is pyridine-derivatives. Now introduce a scientific discovery about this category.
Structural and Electronic Control of the Bidentate 1-(2-pyridyl)benzotriazole Ligand in Copper Chemistry with Application to Catalysis in the A(3) Coupling Reaction
The hybrid bidentate 1-(2-pyridyl)benzotriazole (pyb) ligand was introduced into 3d transition metal catalysis. Specifically, [Cu-II(OTf)(2)(pyb)(2)].2 CH3CN (1) enables the synthesis of a wide range of propargylamines by the A(3) coupling reaction at room temperature in the absence of additives. Experimental and high-level theoretical calculations suggest that the bridging N atom of the ligand imposes exclusive trans coordination at Cu and allows ligand rotation, while the N atom of the pyridine group modulates charge distribution and flux, and thus orchestrates structural and electronic precatalyst control permitting alkyne binding with simultaneous activation of the C-H bond via a transient Cu-I species.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem