Application In Synthesis of 3-Pyridinecarboxaldehyde. I found the field of Biochemistry & Molecular Biology very interesting. Saw the article N-Benzyl Derivatives of Long-Chained 4-Amino-7-chloro-quionolines as Inhibitors of Pyocyanin Production in Pseudomonas aeruginosa published in 2019.0, Reprint Addresses Opsenica, DM; Senerovic, L (corresponding author), Univ Belgrade, Inst Mol Genet & Genet Engn, Vojvode Stepe 444a, Belgrade 11010, Serbia.; Opsenica, DM (corresponding author), Univ Belgrade, ICTM, Ctr Excellence Environm Chem & Engn, Belgrade 11000, Serbia.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.
Pseudomonas aeruginosa is a leading cause of nosocomial infections that are becoming increasingly difficult to treat due to the occurrence of antibiotic resistant strains. Since P. aeruginosa virulence is controlled through quorum sensing, small molecule treatments inhibiting quorum sensing signaling pathways provide a promising therapeutic option. Consequently, we synthesized a series of N-octaneamino-4-aminoquinoline derivatives to optimize this chemotype’s antivirulence activity against P. aeruginosa via inhibition of pyocyanin production. The most potent derivative, which possesses a benzofuran substituent, provided effective inhibition of pyocyanin production (IC50 = 12 mu M), biofilm formation (BFIC50 = 50 mu M), and motility. Experimentally, the compound’s activity is achieved through competitive inhibition of PqsR, and structure-activity data were rationalized using molecular docking studies.
Welcome to talk about 500-22-1, If you have any questions, you can contact Aleksic, I; Jeremic, J; Milivojevic, D; Ilic-Tomic, T; Segan, S; Zlatovic, M; Opsenica, DM; Senerovic, L or send Email.. Application In Synthesis of 3-Pyridinecarboxaldehyde
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem