I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Introducing of potent cytotoxic novel 2-(aroylamino)cinnamamide derivatives against colon cancer mediated by dual apoptotic signal activation and oxidative stress published in 2020.0. SDS of cas: 500-22-1, Reprint Addresses Omar, AM (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah 21589, Saudi Arabia.; Ahmed, HEA (corresponding author), Taibah Univ, Coll Pharm, Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawarah 47114, Saudi Arabia.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde
Curcumin and trans-cinnamaldehyde are acrolein-based Michael acceptor compounds that are commonly found in domestic condiments, and known to cause cancer cell death via redox mechanisms. Based on the structural features of these compounds we designed and synthesized several 2-cinnamamido-N-substituted-cinnamamide (bis-cinnamamide) compounds. One of the derivatives, (Z)-2-[(E)-cinnamamido]-3-phenyl-N-propylacrylamide 8 showed a moderate antiproliferative potency (HCT-116 cell line inhibition of 32.0 mu M), no inhibition of normal cell lines C-166, and proven cellular activities leading to apoptosis. SAR studies led to more than 10-fold increase in activity. Our most promising compound, [(Z)-3-(1H-indol-3-yl)-N-propyl-2-[(E)-3-(thien-2-yl)propenamido) propenamide] 45 killed colon cancer cells at IC50 = 0.89 mu M (Caco-2), 2.85 mu M (HCT-116) and 1.65 mu M (HT -29), while exhibiting much weaker potency on C-166 and BHK normal cell lines (IC50 = 71 mu M and 77.6 mu M, respectively). Cellular studies towards identifying the compounds mechanism of cytotoxic activities revealed that apoptotic induction occurs in part as a result of oxidative stress. Importantly, the compounds showed inhibition of cancer stem cells that are critical for maintaining the potential for self-renewal and stemness. The results presented here show discovery of covalently acting Michael addition compounds that potently kill cancer cells by a defined mechanism, with prominent selectivity profile over non-cancerous cell lines.
Welcome to talk about 500-22-1, If you have any questions, you can contact Omar, AM; El-Araby, ME; Abdelghany, TM; Safo, MK; Ahmed, MH; Boothello, R; Patel, BB; Abdel-Bakky, MS; Malebari, AM; Ahmed, HEA; Elhaggar, RS or send Email.. SDS of cas: 500-22-1
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem