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Application In Synthesis of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Saglik, BN; Cevik, UA; Osmaniye, D; Levent, S; Cavusoglu, BK; Demir, Y; Ilgin, S; Ozkay, Y; Koparal, AS; Beydemir, S; Kaplancikli, ZA or send Email.

An article Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives WOS:000487812000049 published article about BIOLOGICAL EVALUATION; ISOZYMES I; ISOFORMS I; DRUG DESIGN; HYDRAZONE; POTENT; COMPLEXES; XII; SOLUBILITY; ANALOGS in [Saglik, Begum Nurpelin; Cevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Cavusoglu, Betul Kaya; Ozkay, Yusuf; Kaplancikli, Zafer Asim] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey; [Saglik, Begum Nurpelin; Cevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Ozkay, Yusuf] Anadolu Univ, Fac Pharm, Doping & Narcot Cpds Anal Lab, TR-26470 Eskisehir, Turkey; [Demir, Yeliz] Ardahan Univ, Nihat Delibalta Gole Vocat High Sch, Dept Pharm Serv, TR-75700 Ardahan, Turkey; [Ilgin, Sinem] Anadolu Univ, Fac Pharm, Dept Toxicol, TR-26470 Eskisehir, Turkey; [Koparal, Ali Savas] Anadolu Univ, Open Educ Fac, TR-26470 Eskisehir, Turkey; [Beydemir, Sukru] Anadolu Univ, Fac Pharm, Dept Biochem, TR-26470 Eskisehir, Turkey in 2019.0, Cited 60.0. Application In Synthesis of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II isoenzyme were investigated by comparing their IC50 and K-i values. Acetazolamide (5-acetamido-1,3,4-thia-diazole-2-sulfonamide, AZA) has also been used as a standard inhibitor. The compound 3e demonstrated the best hCA I inhibitory effect with a K-i value of 0.1676 +/- 0.017 mu M. Besides, the compound 3m showed the best hCA II inhibitory effect with a K-i value of 0.2880 +/- 0.080 mu M. Cytotoxicity of the compounds 3e and 3m toward NIH/3T3 mouse embryonic fibroblast cell line was observed and the compounds were found to be non-cytotoxic. Molecular docking studies were performed to investigate the interaction types between active compounds and hCA enzymes. Pharmacokinetic profiles of compounds were assessed by theoretical ADME predictions. As a result of this study a novel and potent class of CA inhibitors were identified with a good activity potential.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Saglik, BN; Cevik, UA; Osmaniye, D; Levent, S; Cavusoglu, BK; Demir, Y; Ilgin, S; Ozkay, Y; Koparal, AS; Beydemir, S; Kaplancikli, ZA or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem