An article Anticancer Activity of Platinum (II) Complex with 2-Benzoylpyridine by Induction of DNA Damage, S-Phase Arrest, and Apoptosis WOS:000534475000010 published article about CELL-CYCLE ARREST; G-QUADRUPLEX DNA; METAL-COMPLEXES; CISPLATIN-DNA; TUMOR; INHIBITION; BINDING; RECOGNITION; P53; PROLIFERATION in [Li, Yu-Lan; Gan, Xin-Li; Zhu, Rong-Ping; Jin, Junfei] Guilin Med Univ, Affiliated Hosp, Lab Hepatobiliary & Pancreat Surg, Guilin 541001, Guangxi, Peoples R China; [Li, Yu-Lan; Jin, Junfei] Guilin Med Univ, Guangxi Key Lab Mol Med Liver Injury & Repair, Guilin 541001, Guangxi, Peoples R China; [Li, Yu-Lan; Jin, Junfei] Guilin Med Univ, China USA Lipids Hlth & Dis Res Ctr, Guilin 541001, Guangxi, Peoples R China; [Wang, Xuehong; Huang, Zhaoquan] Guilin Med Univ, Dept Pathol, Affiliated Hosp, 15 Lequn Rd, Guilin 541001, Guangxi, Peoples R China; [Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China; [Li, Yu-Lan] Guangxi Normal Univ, Sch Chem & Pharm, Key Lab Chem & Mol Engn Med Resources, 15 Yucai Rd, Guilin 541004, Peoples R China; [Zhu, Rong-Ping] Nanchang Univ, Ganzhou Peoples Hosp, Dept Emergency Traumat Surg, Affiliated Ganzhou Hosp, Ganzhou 341000, Jiangxi, Peoples R China in 2020.0, Cited 54.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. HPLC of Formula: C12H9NO
Objective: To overcome the disadvantages of cisplatin, numerous platinum (Pt) complexes have been prepared. However, the anticancer activity and mechanism of Pt(II) complexed with 2-benzoylpyridine [Pt(II)-Bpy]: [PtCl2(DMSO)L] (DMSO = dimethyl sulfoxide, L = 2-benzoylpyridine) in cancer cells remain unknown. Methods: Pt(II)-Bpy was synthesized and characterized by spectrum analysis. Its anticancer activity and underlying mechanisms were demonstrated at the cellular, molecular, and in vivo levels. Results: Pt(II)-Bpy inhibited tumor cell growth, especially HepG2 human liver cancer cells, with a half-maximal inhibitory concentration of 9.8 +/- 0.5 mu M, but with low toxicity in HL-7702 normal liver cells. Pt(H)Bpy induced DNA damage, which was demonstrated through a marked increase in the expression of cleaved-poly (ADP ribose) polymerase (PARP) and gamma-H2A histone family member X and a decrease in PARP expression. The interaction of Pt(II)-Bpy with DNA at the molecular level was most likely through an intercalation mechanism, which might be evidence of DNA damage. Pt(II)-Bpy initiated cell cycle arrest at the S phase in HepG2 cells. It also caused severe loss of the mitochondria( membrane potential; a decrease in the expression of caspase-9 and caspase-3; an increase in reactive oxygen species levels; the release of cytochrome c and apoptotic protease activation factor; and the activation of caspase-9 and caspase-3 in HepG2 cells, which in turn resulted in apoptosis. Meanwhile, changes in p53 and related proteins were observed including the upregulation of p53, the phosphorylation of p53, p21, B-cell lymphoma-2-associated X protein, and NOXA; and the down-regulation of B-cell lymphoma 2. Moreover, Pt(II)-Bpy displayed marked inhibitory effects on tumor growth in the HepG2 nude mouse model. Conclusion: Pt(II)-Bpy is a potential candidate for cancer chemotherapy.
About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Li, YL; Gan, XL; Zhu, RP; Wang, XH; Liao, DF; Jin, JF; Huang, ZQ or concate me.. HPLC of Formula: C12H9NO
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem