Safety of Phenyl(pyridin-2-yl)methanone. Recently I am researching about OLD YELLOW ENZYME; COMBINING PHOTOCATALYSIS; BIOCATALYTIC REDUCTION; RADICALS; BOND; DISSOCIATION; REDOX; HETEROCYCLES; BIOREDUCTION; COMPLEXES, Saw an article supported by the NSFNational Science Foundation (NSF) [1846861]; Searle Scholar Program; Sloan Scholar Program; Princeton UniversityPrinceton University; Australian GovernmentAustralian GovernmentCGIAR; DOE Office of ScienceUnited States Department of Energy (DOE) [DE-SC0012704]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Nakano, Y; Black, MJ; Meichan, AJ; Sandoval, BA; Chung, MM; Biegasiewicz, KF; Zhu, TY; Hyster, TK. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone
Flavin-dependent ‘ene’-reductases (EREDs) are highly selective catalysts for the asymmetric reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in the presence of a photoredox catalyst. Experimental evidence suggests the reaction proceeds via a radical mechanism where the vinyl pyridine is reduced to the corresponding neutral benzylic radical in solution. DFT calculations reveal this radical to be dynamically stable, suggesting it is sufficiently long-lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer. This reduction mechanism is distinct from the native one, highlighting the opportunity to expand the synthetic capabilities of existing enzyme platforms by exploiting new mechanistic models.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem