Wise, L. David published the artcileIvermectin for COVID-19: Concerns during pregnancy, Synthetic Route of 72509-76-3, the main research area is polemic COVID 19 ivermectin pregnancy.
A polemic in response to Nicolas et al ( Lancet Glob. Health 8 (2020) e92-100) is given. The author Nicolas et al reviewed the safety of oral ivermectin during human pregnancy and concluded there was insufficient evidence of safety. According to product labeling, ivermectin produced an increase in malformations when given to pregnant mice at less than the human dose on a body surface area basis. The lowest teratogenic dose levels for animals in the 1996 NDA for ivermectin (NDA 50-742) are 0.4 mg/kg/day in mice, 3 mg/kg/day in rabbits, and 10 mg/kg/day in rats. Fetal-placental units deficient in P-glycoprotein were 100% susceptible to cleft palate, while fetuses with full P-glycoprotein expression had 0% cleft palate. A different outbred mouse strain with full P-glycoprotein expression showed no defects at the highest tested dose level (3 mg/kg/day of a related photoisomer). Similarly, as the aforementioned studies of the NDA reported, rats and rabbits required somewhat higher ivermectin doses to induce birth defects due to their full P-glycoprotein expression. Thus, besides the lack of adequate clin. safety of ivermectin in human pregnancies, healthcare providers should be aware of the animal data as an under-appreciated potential risk factor to pregnant women who take ivermectin for Covid-19. A number of coadministration studies in various species have shown increased systemic exposure, organ concentrations, or toxicity of ivermectin. The combination will likely cause an increased level of ivermectin in the developing embryo or fetus, potentially inducing birth defects.
Reproductive Toxicology published new progress about Cleft palate. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Synthetic Route of 72509-76-3.