A Base-Promoted Reductive Coupling Platform for the Divergent Defluorofunctionalization of Trifluoromethylarenes was written by Wright, Shawn E.;Bandar, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2022.Product Details of 175205-82-0 This article mentions the following:
Trifluoromethylarenes ArCF3 [Ar = di-Et phenylphosphonate, 3-(benzyloxy)-5-(trifluoromethyl)phenyl, 3-fluoropyridin-2-yl, etc.] reductive coupling method that dramatically expands the scope of difluorobenzylic substructures ArC(F2)R [R = (hydroxyimino)methyl, (dimethylamino)[(trimethylsilyl)oxy]methyl, morpholin-4-yl[(trimethylsilyl)oxy]methyl, etc.] accessible via C-F bond functionalization was reported. Catalytic quantities of a Lewis base, in conjunction with a disilane reagent in formamide solvent, led to the replacement of a single trifluoromethyl fluorine atom with a silylated hemiaminal functional group. The reaction proceeds through a difluorobenzyl silane intermediate that can also be isolated. Together, these defluorinated products are shown to provide rapid access to over 20 unique difluoroalkylarene scaffolds. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Product Details of 175205-82-0).
2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Product Details of 175205-82-0