Wu, Jiang-Ping published the artcileThe discovery of thienopyridine analogues as potent IκB kinase β inhibitors. Part II, Related Products of pyridine-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(19), 5547-5551, database is CAplus and MEDLINE.
An SAR study that identified a series of thienopyridine-based potent IκB Kinase β (IKKβ) inhibitors is described. With focuses on the structural optimization at C-4 and C-6 of 3-aminothieno[2,3-b]pyridine-2-carboxamide, the study reveals that small alkyl and certain aromatic groups are preferred at C-4, whereas polar groups with proper orientation at C-6 efficiently enhance compound potency. The most potent analogs inhibit IKKβ with IC50s as low as 40 nM, suppress LPS-induced TNF-α production in vitro and in vivo, display good kinase selectivity profiles, and are active in a HeLa cell NF-κB reporter gene assay, demonstrating that they directly interfere with the NF-κB signaling pathway.
Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C2H4ClNO, Related Products of pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem