Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. COA of Formula: C5H4ClNO2S.
Xi, Meiyang;Feng, Chengjie;Du, Kui;Lv, Weiping;Du, Chenxi;Shen, Runpu;Sun, Haopeng research published 《 Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors》, the research content is summarized as follows. N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4-yl)methyl)benzo[d] [1,3]dioxole-5-carboxamide (1) and its 33 analogs I [R1 = p-tolyl, Me, p=fluorophenyl, etc.; R2 = Me, isobutyl; R3 = Me, benzo[d][1,3]dioxolyl, Ph, etc.; X = CO, SO2] were synthesized and assessed by AChE/BuChE activities, indicating an optimal compound I [R1 = p-tolyl; R2 = isobutyl; R3 = benzo[d][1,3]dioxolyl;X = CO]. Further kinetic tests suggested a competitive manner. Mol. docking and Mol. dynamics (MD) simulation showed that it interacted with several residues in active site gorge of BuChE, possibly contributing to its selectivity and competitive pattern. Moreover, it showed low cytotoxicity and high blood brain barrier (BBB) permeability. Taken together, compound I [R1 = p-tolyl; R2 = isobutyl; R3 = benzo[d][1,3]dioxolyl;X = CO] was a promising BuChE inhibitor for the treatment of AD.
COA of Formula: C5H4ClNO2S, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.