Piperazine Sulfonamides as Potent, Selective, and Orally Available 11灏?Hydroxysteroid Dehydrogenase Type 1 Inhibitors with Efficacy in the Rat Cortisone-Induced Hyperinsulinemia Model was written by Xiang, Jason;Wan, Zhao-Kui;Li, Huan-Qiu;Ipek, Manus;Binnun, Eva;Nunez, Jill;Chen, Lihren;McKew, John C.;Mansour, Tarek S.;Xu, Xin;Suri, Vipin;Tam, May;Xing, Yuzhe;Li, Xiangping;Hahm, Seung;Tobin, James;Saiah, Eddine. And the article was included in Journal of Medicinal Chemistry in 2008.HPLC of Formula: 175205-82-0 This article mentions the following:
11灏?Hydroxysteroid dehydrogenase type 1 (11灏?HSD1) is the enzyme that converts cortisone to cortisol. Evidence suggests that selective inhibition of 11灏?HSD1 could treat diabetes and metabolic syndrome. Presented herein are the synthesis, structure-activity relationship, and in vivo evaluation of piperazine sulfonamides as 11灏?HSD1 inhibitors. Through modification of our initial lead I (R1 = 3,4-Cl2, R2 = H, X = N), we have identified potent and selective 11灏?HSD1 inhibitors such as I [R1 = 3-(1,2,4-triazol-1-yl), 3-(MeO2CCMe2O), R2 = F, X = C] with good pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0HPLC of Formula: 175205-82-0).
2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.HPLC of Formula: 175205-82-0