RuHCl(CO)(PPh3)3-Catalyzed Direct Amidation of Arene C-H Bond with Azides was written by Xiao, Xinsheng;Jia, Guokai;Liu, Fang;Ou, Guangchuan;Xie, Ying. And the article was included in Journal of Organic Chemistry in 2018.COA of Formula: C12H11N This article mentions the following:
The direct ortho C-H amidation of arenes with azides by using an inexpensive RuHCl(CO)(PPh3)3 catalyst, it reported. The reaction proceeds efficiently in high yield over a broad range of substrates without requirement of any addnl. silver salt or additive. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9COA of Formula: C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.COA of Formula: C12H11N