On August 31, 2020, Xu, Guangpeng; Zhang, Yajing; Sun, Jihong; Bai, Shiyang; Zhao, Hongwu published an article.Electric Literature of 75449-26-2 The title of the article was Synthesis of Extended Bipyridine-proline Chiral Catalysts and Resulting Effects on the Asymmetric Aldol Reactions of Bulkier Aldehyde Derivatives with Cyclohexanone. And the article contained the following:
Axially-unfixed 2,2′-bipyridine-based chiral catalysts were synthesized using enantiopure amino acids as chiral sources, which were successfully used in asym. aldol reactions of p-nitrobenzaldehyde with cyclohexanone, while the bulkier aldehyde derivatives (2-naphthaldehyde, 9-anthracenecarboxaldehyde, and 1-pyrenecarboxaldehyde) were selected to further elucidate the catalytic properties. Particularly, the influences of the bipyridine-proline chiral structures and the polarities of used solvents (petroleum ether, toluene, CH2Cl2, ethanol, DMF, DMSO, and water) on the catalytic performance were investigated. The results indicated that the structure of bipyridine catalysts, the mol. volume of aldehydes, and the polarity of solvents have significant effects on the catalytic activities, in which, the smaller steric effects were conducive to the improvement of the yields and stereoselectivities for asym. aldol reaction, along with the increased polarity of used solvents and the decreased mol. volume of aldehydes. Meanwhile, the chem. identity of all compounds was confirmed by 1H-NMR, 13C-NMR, HRMS, and HPLC anal. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2
The Article related to bipyridinyl proline preparation, cyclohexanone aryl aldehyde bipyridinyl proline catalyst diastereoselective aldol reaction, aryl hydroxymethyl cyclohexanone preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 75449-26-2