Name: 4-CyanopyridineIn 2021 ,《Metal-Free Hydropyridylation of Thioester-Activated Alkenes via Electroreductive Radical Coupling》 was published in Journal of Organic Chemistry. The article was written by Xu, Hehuan; Liu, Jiayu; Nie, Feiyun; Zhao, Xiaowei; Jiang, Zhiyong. The article contains the following contents:
An electrochem. hydropyridylation of thioester-activated alkenes R1R2C:CHC(O)SEt (R1 = Ph, 2-MeOC6H4, 3-BrC6H4, 1-naphthyl, N-Boc-indol-3-yl, etc.; R2 = H, Me, n-Bu) with 4-cyanopyridines has been developed. The reactions proceed via tandem electroreduction of both substrates on the cathode surface, protonation and radical cross-coupling processes, resulting in a variety of valuable pyridine variants, which contain a tertiary and even a quaternary carbon at the α-position of pyridines in high yields. These reactions require no catalyst or high temperature representing a highly sustainable synthetic method. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 4-Cyanopyridine