Xu, Lei; Liu, Fu-Yue; Zhang, Qi; Chang, Wei-Jun; Liu, Zhong-Lin; Lv, Ying; Yu, Hai-Zhu; Xu, Jun; Dai, Jian-Jun; Xu, Hua-Jian published an article on January 31 ,2021. The article was titled 《The amine-catalysed Suzuki-Miyaura-type coupling of aryl halides and arylboronic acids》, and you may find the article in Nature Catalysis.Product Details of 39856-58-1 The information in the text is summarized as follows:
A robust and chemoselective organocatalytic Suzuki-Miyaura-type coupling of aryl halides viz. Me 2-(4-bromophenyl)propanoate, Me 2-(4-chlorophenyl)propanoate, 5-bromopyrimidine, etc. with arylboronic acids viz. phenylboronic acid, naphthalen-2-ylboronic acid, furan-3-ylboronic acid, etc. catalyzed by amines, e.g. 2-methyl-N1,N3-di-o-tolylbenzene-1,3-diamine was reported. The utility and scope of this reaction were demonstrated by the synthesis of several com. relevant small mols. viz. Me 2-([1,1′-biphenyl]-4-yl)propanoate, Me 2-(4-(naphthalen-2-yl) phenyl)propanoate, 5-(furan-3-yl)pyrimidine, etc. and a selection of derivatives of pharmaceutical drugs e.g., Boscalid. The experimental process involved the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Product Details of 39856-58-1)
2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Product Details of 39856-58-1