Formula: C6H6BrNIn 2021 ,《Palladium-catalyzed dearomative cyclocarbonylation of allyl alcohol for the synthesis of quinolizinones》 appeared in Organic & Biomolecular Chemistry. The author of the article were Xu, Pengcheng; Qian, Bo; Qi, Zaojuan; Gao, Bao; Hu, Bin; Huang, Hanmin. The article conveys some information:
An approach for the synthesis of quinolizinone I (R = H, 6-Me, 7-F, etc.; R1 = H, Me, Ph; R2 = H, Me, pentyl; R3 = H, Me; X = N, CH) with potential bioactivity has been developed via palladium-catalytic dearomative cyclocarbonylation of allyl alc. R4C(R1)=C(R2)CH(R3)OH (R4 = pyridin-2-yl, 5-fluoropyridin-2-yl, pyrazin-2-yl, etc.). Diverse quinolizinone compounds I could be attained with good efficiencies. A feasible reaction pathway could be a successive procedure of allylation, dearomatization, CO insertion and the Heck reaction. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Formula: C6H6BrN