On April 24, 2014, Xu, Wei; Wang, Yong; Ma, Sunghoon; Koltun, Elena S.; Kim, Byung Gyu; Jeong, Joon Won; Dhar, T.g. Murali; Bannen, Lynn Canne published a patent.Recommanded Product: 4-Chloro-2,6-difluoropyridine The title of the patent was Pyrimidine derivatives as RORγ modulators and their preparation. And the patent contained the following:
Described are RORγ modulators of formula I, and N-oxides, pharmaceutically acceptable salts, solvates and hydrates thereof, and their compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune. Compounds of formula I wherein R1 is H, halo, CN, NO2, OH, etc.; dashed bonds are single and double bond; R2 is H, halo, CN, NO2, N3, etc.; R4 and R5 are independently H, Me and F; m and n are independently 0, 1, 2, and 3; each R6 is halo, CN, NO2, N3, OH, etc.; each Ra is H, halo, CN, NO2, etc.; Z is CO, CS, SO2 and CH2; G is a single bond, CH2, CHD, CD2, etc.; B is Ph, pyridyl, naphthyl, thiazolyl and pyrimidinyl; L is CONHCH2, CONHCH2CH2O, oxadiazolyl, etc.; A is Ph, pyridyl, pyrimidinyl, thiazolyl, pyrazolyl and pyrazinyl; and stereoisomeric forms, N-oxides, pharmaceutically acceptable salts, solvates and hydrates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their RORγ modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 4.7 nM. The experimental process involved the reaction of 4-Chloro-2,6-difluoropyridine(cas: 34968-33-7).Recommanded Product: 4-Chloro-2,6-difluoropyridine
The Article related to pyrimidine preparation rorgamma modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 4-Chloro-2,6-difluoropyridine