《Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source》 was written by Xu, Yiwen; Shen, Bei; Liu, Lingfeng; Qiao, Chunhua. Name: 5-Bromo-2-chloropyridineThis research focused ontriazolopyridine preparation; hydrazinylpyridine amide annulation imidazolium chloride catalyst; triazine preparation; biguanide amide annulation imidazolium chloride catalyst. The article conveys some information:
A highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare 1,2,4-triazolo[3,4-a]pyridines, e.g., I and triazines II [R = H, Me, Ph, 2-MeC6H4, 3-ClC6H4; R1 = H, Me; RR1 = (CH2)2O(CH2)2; R2 = H, Ph] was reported. This metal free reaction took advantages of shelf stable DMF as solvent and carbon donor, imidazolium chloride as a catalyst, the mild reaction condition tolerated a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allowed further introduction of a variety of functional groups at 3-position.5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine) was used in this study.
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 5-Bromo-2-chloropyridine