Yakhontov, L. N.; Lapan, E. I. published the artcile< Azaindole derivatives. XLI. Synthesis of 3-substituted 5-azaindoles>, Application In Synthesis of 23612-36-4, the main research area is substitution azaindole electrophilic; nitration azaindole; bromination azaindole; cyanomethylation azaindole; Mannich reaction azaindole.
Bromination of 5-azaindole (I, R = H) with Br in dioxane gave 3-bromo-5-azaindole (II, R = H, R1 = Br) quant. Nitration of I (R = H) gave 3-nitro-5-azaindole (II, R = H, R1 = NO2) quant. 5-Azagramine (II, R = H, R1 = CH2NMe2) was obtained in 92% yield by a Mannich reaction with Me2NH and CH2O. Analogously 13% 1-phenyl-5-azagramine (II, R = Ph, R1 = CH2NMe2) was obtained. Cyanomethylation of I (R = H) yielded 23% azaindole III (R = H), which, when heated with KOH gave 31% acid II (R = H, R1 = CH2CO2H).
Khimiya Geterotsiklicheskikh Soedinenii published new progress about Bromination. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Application In Synthesis of 23612-36-4.