Yakovlev, Ivan A.; Mikhailov, Artem A.; Eremina, Julia A.; Klyushova, Lyubov S.; Nadolinny, Vladimir A.; Kostin, Gennadiy A. published the artcile< Nitric oxide release and related light-induced cytotoxicity of ruthenium nitrosyls with coordinated nicotinate derivatives>, Application In Synthesis of 93-60-7, the main research area is synthesis ruthenium nitrosyl nicotinate complex nitric oxide release; ruthenium nitrosyl nicotinate complex photoinduced cytotoxicity.
The synthetic approaches for the preparation of trans(NO,OH)-cis(NO2,NO2)-[RuNO(L)2(NO2)2OH], where L = Et nicotinate (1) and Me nicotinate (2), are reported. The structures of the complexes were characterized by x-ray diffraction and analyzed by Hirshfeld surface anal. Both compounds show a nitric oxide release reaction under 445 or 532 nm irradiation of DMSO solutions, which was studied by combined UV-visible- (UV-visible), IR- (IR), and EPR spectroscopy and d. functional theory (DFT) calculations The charge transfer from the OH-Ru-NO chain and nitrite ligands to the antibonding orbitals of Ru-NO is responsible for the photo-cleavage of the ruthenium-nitrosyl bond. The elimination of NO leads to a side reaction, the protonation of the parent hydroxyl compound The cytotoxicity and photo-induced cytotoxicity investigations of both compounds on the breast adenocarcinoma cell line MCF-7 reveal that (1) and (2) are cytotoxic with IC50 values of 27.5 ± 2.8μM and 23.3 ± 0.3μM, resp. Also, (1) shows an increase of the toxicity after light irradiation by 7 times (IC50 = 4.1 ± 0.1), which makes it a prominent target for deeper biol. investigations.
Dalton Transactions published new progress about Antitumor agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.