In 2017,Yamamoto, Yoshihiko; Nishimura, Kei-ichiro; Shibuya, Masatoshi published 《Ruthenium-Catalyzed Cycloisomerization of 1,6-Diynes with Styryl Terminals Leading to Indenylidene Cycloalkanes》.ACS Catalysis published the findings.COA of Formula: C6H4BrNO The information in the text is summarized as follows:
In the presence of a neutral ruthenium catalyst, Cp*RuCl(cod), 1,5,10-enediynes bearing a styryl terminal underwent cycloisomerization to afford exocyclic 1,3-dienes with an indenylidene moiety. The reaction mechanism is proposed on the basis of the results of control experiments and d. functional calculations The transformations of the obtained cyclization products were also investigated to demonstrate the synthetic potential of this method. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0COA of Formula: C6H4BrNO) was used in this study.
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H4BrNO