Yang, Huan; Zhang, Li; Zhou, Fei-Yu; Jiao, Lei published the artcile< An umpolung approach to the hydroboration of pyridines: a novel and efficient synthesis of N-H 1,4-dihydropyridines>, Name: 3-(Methoxycarbonyl)pyridine, the main research area is diboron pyridine inverse hydroboration deuteration; dihydropyridine preparation.
The first inverse hydroboration of pyridine with a diboron compound and a proton source was realized under simple basic and catalyst-free conditions. This process consisted of a formal boryl anion addition to pyridine, which produced an N-boryl pyridyl anion complex and the subsequent protonation of the anion complex. This process enabled a simple and efficient method for the synthesis of multi-substituted N-H 1,4-dihydropyridine (1,4-DHP) derivatives that were difficult to prepare using established methods. Furthermore, this method allowed facile preparation of 4-deuterated 1,4-DHPs from an easily accessible deuterium ion source. This inverse hydroboration reaction represented a new mode for pyridine functionalization.
Chemical Science published new progress about Deuteration, regioselective. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Name: 3-(Methoxycarbonyl)pyridine.