Asymmetrical synthesis of fluorinated 2-(pyridin-2-yl) alkylamine from fluoromethyl sulfinyl imines and 2-alkylpyridines was written by Yang, Jialin;Zhang, Jiali;Meng, Weidong;Huang, Yangen. And the article was included in Tetrahedron Letters in 2015.Product Details of 644-98-4 This article mentions the following:
A novel strategy was developed to synthesize fluorinated 2-(pyridin-2-yl) alkylamines via condensation of 2-alkylpyridines and chiral fluoromethyl N-tert-Bu sulfinyl imines with good diastereo-control and good chem. yields. The chiral N-tert-Bu sulfinyl auxiliary can be easily removed under mild acidic condition at room temperature The application of this strategy was demonstrated in the synthesis of a fluorine-containing pesticide candidate. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Product Details of 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 644-98-4