A facile approach to synthesize NH-3-aryloxindoles at room temperature by Rh(III)-catalyzed C-H activation was written by Yang, Ning-Hong;Ding, Hao-Sheng;Zheng, Yang;Yang, Zhong-Zhen;Guan, Mei;Wu, Yong. And the article was included in Catalysis Communications in 2020.Synthetic Route of C12H11N This article mentions the following:
The Rh(III)-catalyzed directed C-H activation/carbenoid coupling reactions for the synthesis of NH-3-aryloxindoles, e.g., I, is described. This mild, highly efficient and time-economical coupling reaction displays excellent functional group compatibility and regioselectivity. This methodol. provided the straightforward way for the synthesis of NH-3-aryloxindoles, which might be of considerable bioactivities. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Synthetic Route of C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C12H11N