《Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells》 was published in Journal of Asian Natural Products Research in 2018. These research results belong to Yang, Qian-Hao; Jiang, Cheng-Shi; Jin, Tao; Xu, Jin-Fang; Qu, Ting-Li; Guo, Yue-Wei; Zhao, Zheng-Bao. Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid The article mentions the following:
A series of novel tetrandrine (Tet) derivatives were synthesized through Suzuki -Miyaura reaction and evaluated for their cytotoxicity against human non-small cell lung carcinoma (NSCLC) A549 cells. Interestingly, most of derivatives showed similar cytotoxicity to Tet against NSCLC A549 cells, and particularly, compounds Y5, Y6, Y9 and Y11 showed the most significant cytotoxic effects with IC50 values ranging from 3.87 to 4.66 mM. The present study is expected to contribute to the future design of more effective anticancer agents in lung cancer chemotherapy. The results came from multiple reactions, including the reaction of (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid)
(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid