Improved synthesis of 6-cyano-1-hydroxy-7-methyl-5-oxo-3,5-dihydro-indolizine-2-carboxylic acid methyl ester was written by Yang, Song;Zhang, Wannian;Zhou, Youjun;Yao, Jianzhong;Ji, Haitao. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2004.COA of Formula: C10H10N2O3 The following contents are mentioned in the article:
The synthesis of 6-cyano-1-hydroxy-7-methyl-5-oxo-3,5-dihydro-indolizine-2-carboxylic acid Me ester, an intermediate of the total synthesis of camptothecins, was improved. The yield of Et acetopyruvate was raised by controlling the speed of dropping and reaction time. The “one-pot procedure” was taken to prepare the title compound from Et acetopyruvate. The overall yield of the title compound was raised from 31% to 42.5%, and its structure of was confirmed by 1H-NMR, MS and EA. The synthesis process was improved by the simplified operation, raised yield, shortened reaction time and the reduced usage of reagent. This study involved multiple reactions and reactants, such as Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate (cas: 58610-61-0COA of Formula: C10H10N2O3).
Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate (cas: 58610-61-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C10H10N2O3