Yang, Wenjun; Chernyshov, Ivan Yu.; van Schendel, Robin K. A.; Weber, Manuela; Mueller, Christian; Filonenko, Georgy A.; Pidko, Evgeny A. published the artcile< Robust and efficient hydrogenation of carbonyl compounds catalysed by mixed donor Mn(I) pincer complexes>, Application In Synthesis of 350-03-8, the main research area is alc preparation; carbonyl compound hydrogenation manganese catalyst.
A highly efficient Mn(I)-CNP pre-catalyst I which gives rise to the excellent productivity (TOF° up to 41 000 h-1) and stability (TON up to 200 000) in hydrogenation catalysis was reported. This system enables near-quant. hydrogenation of ketones RC(O)R1 (R = Ph, 2,3-dihydro-1,4-benzodioxin-6-yl, pentyl, etc.; R1 = Et, Bn, cyclopropyl, etc.; RR1 = -(CH2)5-) and 1,2,3,4-tetrahydronaphthalen-1-one, imines 4-R2C6H4N=CHC6H5 (R2 = H, Br, OMe), aldehydes R3CHO [R3 = Ph, 4-(dimethylamino)phenyl, 4-(benzyloxy)phenyl, furan-2-yl] and formate esters R4OC(O)H (R4 = hexyl, pentyl, 3-methylbutyl) at the catalyst loadings as low as 5-200 p.p.m. The anal. points to the crucial role of the catalyst activation step for the catalytic performance and stability of the system. While conventional activation employing alkoxide bases can ultimately provide catalytically competent species under hydrogen atm., activation of Mn(I) pre-catalyst I with hydride donor promoters, e.g., KHBEt3, dramatically improves catalytic performance of the system and eliminates induction times associated with slow catalyst activation.
Nature Communications published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.