Yang, Yang published the artcileSynthetic versatility of 2-substituted-6-methyl 2,3-dihydropyridinones in the synthesis of polyfunctional piperidine-based compounds and related β amino acid derivatives, Recommanded Product: 2-Pyridinylboronic acid, the publication is Organic & Biomolecular Chemistry (2017), 15(40), 8576-8593, database is CAplus and MEDLINE.
Chiral 2-substituted-6-Me 2,3-dihydropyidinones (I) (R1 = cyclohexyl, n-pentyl, CH2TBSO, n-butyl), which can be facilely obtained from an asym. vinylogous Mannich reaction (VMR) with 1,3-bis-trimethylsilyl enol ether, were used as versatile intermediates in constructing chiral polyfunctional piperidine-based compounds The 6-Me group of such compounds can be conveniently functionalized via alkylation and acylation reactions to provide efficient entries to the synthesis of a variety of chiral multi-substituted piperidine-based compounds Further elaboration of the corresponding intermediates also provided access to polyfunctional indolizidine-based compounds These methods were showcased in an asym. synthesis of 2,6-di-substituted piperidine compound (II), reported as the key intermediate in the synthesis of (+)-calvine and a natural alkaloid (-)-indolizidine 209D. Furthermore, selective C5 iodination of compound I enabled the installation of addnl. functional groups at this position. Finally, we demonstrated that the oxidative cleavage of 2-substituted-6-methyl-2,3-dihydropyidinones is a practical and efficient method for the enantioselective synthesis of β-amino acids, which can undergo further intra-mol. cyclization to give the corresponding chiral four-membered β-lactam derivatives
Organic & Biomolecular Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C13H18BNO3, Recommanded Product: 2-Pyridinylboronic acid.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem