Rhodium-Catalyzed Asymmetric Conjugate Pyridylation with Pyridylboronic Acids was written by Ye, Bihai;Yao, Jian;Wu, Changhui;Zhu, Huilong;Yao, Weijun;Jin, Lili;Dou, Xiaowei. And the article was included in ACS Catalysis in 2022.Computed Properties of C5H4BCl2NO2 This article mentions the following:
In this study, the rhodium-catalyzed asym. conjugate pyridylation of α,β-unsaturated carbonyl compounds with pyridylboronic acids was reported. The bifunctional chiral amide-diene ligand, which dramatically accelerated the reaction via possible H-bonding activation, and alc. solvent, which significantly inhibited the competing protodeboronation of pyridylboronic acids under rhodium catalysis, worked in concert to promote the reaction, thus enabling production of the pyridylation products in high yields (up to 99%) with good enantioselectivities (up to >99% ee). In the experiment, the researchers used many compounds, for example, (2,6-Dichloropyridin-4-yl)boronic acid (cas: 1072951-54-2Computed Properties of C5H4BCl2NO2).
(2,6-Dichloropyridin-4-yl)boronic acid (cas: 1072951-54-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Computed Properties of C5H4BCl2NO2