At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Application of C5H3BrFN.
Ye, Pengqing;Shao, Yinlin;Zhang, Fangjun;Zou, Jinxuan;Ye, Xuanzeng;Chen, Jiuxi research published 《 Rare-Earth-Metal-Catalyzed Synthesis of Azaindolines and Naphthyridines via C-H Cyclization of Functionalized Pyridines》, the research content is summarized as follows. A rare-earth-metal-catalyzed insertion of a 2-pyridine C(sp2)-H bond into an intramol. unactivated vinyl bond was reported. This reaction provides streamlined access to a range of azaindolines in moderate to excellent yields. The salient features of this reaction include simple and mild reaction conditions, 100% atom efficiency, and wide substrate scope. This methodol. is also used to construct other nitrogen-containing compounds such as naphthyridine derivatives A plausible mechanism for the formation of azaindolines involving initial C-H bond activation by the lanthanide complex followed by C=C insertion into a Ln-C bond to form an alkyl lanthanide species that subsequently undergoes cyclization was proposed.
766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Application of C5H3BrFN