《Rare-Earth-Metal-Catalyzed Synthesis of Azaindolines and Naphthyridines via C-H Cyclization of Functionalized Pyridines》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Ye, Pengqing; Shao, Yinlin; Zhang, Fangjun; Zou, Jinxuan; Ye, Xuanzeng; Chen, Jiuxi. Category: pyridine-derivatives The article mentions the following:
A rare-earth-metal-catalyzed insertion of a 2-pyridine C(sp2)-H bond into an intramol. unactivated vinyl bond was reported. This reaction provides streamlined access to a range of azaindolines in moderate to excellent yields. The salient features of this reaction include simple and mild reaction conditions, 100% atom efficiency, and wide substrate scope. This methodol. is also used to construct other nitrogen-containing compounds such as naphthyridine derivatives A plausible mechanism for the formation of azaindolines involving initial C-H bond activation by the lanthanide complex followed by C=C insertion into a Ln-C bond to form an alkyl lanthanide species that subsequently undergoes cyclization was proposed. In addition to this study using 5-Bromo-2-chloropyridine, there are many other studies that have used 5-Bromo-2-chloropyridine(cas: 53939-30-3Category: pyridine-derivatives) was used in this study.
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives