The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Monobromination of α,ω-Diols: Highly Efficient Preparation of Synthetic Intermediates, the main research direction is bromoalc preparation; diol monobromination reaction.Safety of 8-Bromooctan-1-ol.
The present work aimed to evaluate different conditions to perform monobromination reactions of α,ω-diols HOCH2(CH2)nCH2OH (n = 4, 5, 6, 8) using HBr. Three solvents such as, toluene, isooctane, 1,2-dichloroethane were tested in two distinct molar proportions between 1,8-octanediol and HBr (1:1 and 1:2 equiv). All reactions occurred under reflux. After establishing the best reactional conditions, assays with four sym. α,ω-diols, 1,6-hexanediol; 1,7-heptanediol; 1,8-octanediol; and 1,10-decanediol, with 2 equivalent HBr in 1,2-dichloroethane, were conducted. Using toluene as solvent lead to the best reaction yields (81-95%), producing the least amount of unwanted dibrominated product BrCH2(CH2)nCH2Br. Reactions in 1,2-dichloroethane gave similar results to the ones with toluene when 2 equivalent HBr were used. The lowest reactional efficiency registered in these assays occurred in isooctane, forming the highest amount of dibromide. Diols 1,7-heptanediol and 1,8-octanediol showed the best results under the conditions studied, in 1,2-dichloroethane.
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