On March 15, 2013, Youngvises, Napaporn; Chaida, Thanatcha; Khonyoung, Supada; Kuppithayanant, Nattawan; Tiyapongpattana, Warawut; Itharat, Arunporn; Jakmunee, Jaroon published an article.Category: pyridine-derivatives The title of the article was Greener liquid chromatography using a guard column with micellar mobile phase for separation of some pharmaceuticals and determination of parabens. And the article contained the following:
In this research, a greener chromatog. employing a short column, Zorbax SB C18 cartridge (12.5 × 4.6 mm, 5 μm) commonly used as a guard column in a reverse phase high performance liquid chromatog. (RP-HPLC), was utilized as the anal. column in conjunction with a more eco-friendly micellar mobile phase of sodium dodecyl sulfate (SDS) for separation tertiary mixtures of local anesthetics and antihistamines; and binary mixture of colds drugs; and quaternary mixture of some parabens with different separation conditions. The chromatog. behavior of these analytes was studied to demonstrate separation efficiency of this guard column in a micellar mobile phase. Moreover, this column and SDS mobile phase was exploited for determination of parabens in 64 samples of cosmetic product, both those that were produced locally in the community and those that were com. manufactured Linear calibration graphs of the parabens as detected at 254 nm were obtained in the range of 1-100 μmol L-1 with R2>0.9990. Percentage recoveries were 92.4-109.2 with %RSD<3, and the limit of detection and quantitation were 0.04-0.10 and 0.20-0.80 μmol L-1, resp. This anal. system is not only greener but also faster and employing simpler sample preparation than a conventional liquid chromatog. system. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives
The Article related to green liquid chromatog micelle mobile pharmaceutical paraben, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Category: pyridine-derivatives